The FTSE MIB fell 0.2% to close at 51,604 on Wednesday, pressured by energy producers and continued volatility in AI-related stocks.
ENI dropped 2.6% and Saipem lost 3.5% as restored oil exports from the Middle East lowered global prices.
AI-related stocks weakened following their rally this week, with STMicroelectronics (-3.3%) and Prysmian (-2.2%) posting notable losses.
Meanwhile, defense stocks advanced after the UK announced a reallocation of €15 billion in defense spending, boosting Leonardo (+4.4%), Fincantieri (+1.5%), and Avio (+1.1%).
Banking stocks were mixed following softer-than-expected inflation data in the Eurozone, with UniCredit adding 0.5%.
Also on the financial front, Unipol added 3.9% after receiving an upgrade from Intermonte.
Nexi soared 6.4% on a strong session for payment infrastructure globally.