The FTSE MIB Index fell 451 points or 0.85 percent on Wednesday to close at 52411 points.
Leading the losses are STMicroelectronics (-4.34%), Prysmian (-2.67%) and Avio (-2.52%).
Top gainers were Nexi (4.52%), Stellantis N.V. (3.86%) and Brunello Cucinelli (3.31%).