Karyopharm implemented a 2026 Leadership Cash Retention Program awarding lump-sum cash retention payments to Richard Paulson, Stuart Poulton, Dr. Reshma Rangwala and Lori Macomber.

IndividualRichard PaulsonStuart PoultonDr. Reshma RangwalaLori MacomberRolePresident and Chief Executive OfficerExecutive Vice President, Chief Development OfficerExecutive Vice President, Chief Medical Officer and Head of ResearchExecutive Vice President, Chief Financial Officer and TreasurerType of ChangeRetention awardRetention awardRetention awardRetention awardEffective DateJuly 13, 2026July 13, 2026July 13, 2026July 13, 2026ReasonTo incentivize retention during period of expected meaningful catalystsTo incentivize retention during period of expected meaningful catalystsTo incentivize retention during period of expected meaningful catalystsTo incentivize retention during period of expected meaningful catalystsReplacement InfoNot disclosedNot disclosedNot disclosedNot disclosedBackground DetailsN/AN/AN/AN/ABoard/Committee Role ChangesNot disclosedNot disclosedNot disclosedNot disclosedAward Amount$1,725,000$640,000$725,000$625,000Repayment/Clawback TermsAwards may be subject to repayment if employment terminates for reasons other than Company without cause, participant for good reason, death or permanent disability prior to the earlier of (i) 12 months from payment or (ii) 30 days following a qualifying corporate event; amounts reduce previously agreed severance amounts.

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